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DAILY NEWS ANALYSIS
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01 December, 2020
3 Min Read
Researchers at Sweden’s Karolinska institute have tried to answer why influenza infections lead to an increased risk of bacterial pneumonia. They have described findings leading to so-called “superinfections”.
They cite the example of Spanish flu, which was an influenza pandemic that swept across the world in 1918–20. Unlike many other pandemics, the Spanish flu hit young healthy adults, due to the superinfections caused by bacteria, in particular pneumococci.
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Superinfections: These are infections occurring after or on top of an earlier infection, especially following treatment with broad-spectrum antibiotics. It is an overgrowth of an opportunistic pathogen from the bacterial or yeast imbalance of systemic antibiotics. For example, influenza is caused by a virus, but the most common cause of death in influenza patients is secondary pneumonia, which is caused by bacteria. However, the reason behind influenza infections leading to an increased risk of bacterial pneumonia is not known. |
Researchers looked at the mechanisms behind this increased susceptibility. They found that different nutrients and antioxidants leak from the blood. This creates an environment in the lungs that favours the growth of bacteria.
The bacteria adapt to the inflammatory environment by increasing the production of HtrA enzyme. HtrA weakens the immune system and promotes bacterial growth in the influenza-infected airways. The results of the research could be used to find new therapies for double infections between the influenza virus and pneumococcal bacteria.
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Influenza
Pneumonia
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Source: IE
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