Antibody-dependent enhancement (ADE)

Antibody-dependent enhancement (ADE), sometimes less precisely called immune enhancement or disease enhancement, is a phenomenon in which the binding of a virus to non-neutralizing antibodies enhances its entry into host cells, and sometimes also its replication.
This phenomenon—which leads to both increased infectivity and virulence—has been observed with mosquito-borne flaviviruses such as Dengue virus, Yellow fever virus and Zika virus, with HIV, and with coronaviruses.

An ongoing question in the COVID-19 pandemic is whether—and if so, to what extent—COVID-19 receives ADE from prior infection with other coronaviruses.

Source: WEB

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